Beta-lactamase



Beta-lactamase (Blac) are enzymes which make bacteria resitant to β-lactam antibiotics by breaking their β-lactam ring. Blac are classified according to their resistance targets. Class C are cephalosporinases; Class A are broad-spectrum; Class B are metalloenzymes;  Class D are cloxacilanases.

β-lactamase class A
3dtm - EcBlac A residues 24-286 (mutant) - Escherichia coli

3c7u, 3c7v – EcBlac A (mutant) + Protein Blip

1axb - EcBlac A (mutant) + transition state analog

1tem - EcBlac A (mutant) + penicillanic acid derivative

1o7e – Blac – Stenotrophonas maltophilia

β-lactamase class B
3fcz, 3i0v, 3i11, 3i13, 3i14, 3i15 – BcBlac B - Bacillus cereus

3knr, 3kns - BcBlac C (mutant)

β-lactamase class C
3fkw, 3iwi, 3iwo, 3iwq, 3ixd – EcBlac C (mutant)

3bm6, 3fkv, 3o86, 3o87, 3o88 – EcBlac C + boronic acid derivative

3ixb, 3ixg - EcBlac C (mutant) + boronic acid derivative

3ixh - EcBlac C (mutant) + cefotaxime

3gqz, 3gr2, 3grj, 3gsg, 3gtc, 3gv9, 3gvb - EcBlac C + inhibitor

β-lactamase class D
2rl3, 1k55, 1k57, 1k4e, 1ewz, 1fof – PaBlac D – Pseudomonas aeruginosa

2hp5, 2hp6, 2hp9, 2hpb - PaBlac D (mutant)

1k6r - PaBlac D + moxalactam

1k6s - PaBlac D + phenylboronic acid

1k54 - PaBlac D + penicillanic acid derivative

1bsg – Blac – Streptomyces albus